http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-PI0707910-A2
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_85067b2fb5eade08a0302ffac7cd2571 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D265-30 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D265-30 |
filingDate | 2007-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1db5b6fa78fef425aa4ebfab7a0f39b |
publicationDate | 2011-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | BR-PI0707910-A2 |
titleOfInvention | Process for preparing 2- (4-hydroxy-3-morpholinyl) -2-cyclohexenone |
abstract | PROCESS FOR PREPARING 2- (4-HYDROXY-3-MORPHOLINYL) -2-CYCLOHEXENONE. A process for the preparation of 2- (4-hydroxy-3-morpholinyl) -2-cyclohexenone (BTG-1675A) is described which comprises the steps of: 1) reacting N-hydroxymorpholine with cyclohexenone in the presence of an oxidizing agent to obtain thus is an isoxazolidine of Formula IV; and ii) converting the isoxazolidine of Formula IV to 2- (4-hydroxy-3-morpholinyl) -2-cyclohexenone. Advantageously, the oxidizing agent of step i) is selected from the group consisting of azodicarboxylic acid metal oxides, esters and amides and the conversion step ii) is conducted by basic catalysis followed by trituration into an aromatic hydrocarbon, preferably toluene. The described process makes it possible to obtain BTG-1675A according to the invention in an amount of hundreds of grams and on an industrial scale. The invention further relates to a novel process for the preparation of hydroxylamines, particularly N-hydroxymorpholine, which are used in the process for the preparation of BTG-1675A. |
priorityDate | 2006-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 82.