| abstract |
SYNTHESIS OF SIALIC ACID IN PLANTS. A method of synthesizing sialic acid is provided in plants, and plants capable of synthesizing sialic acid. In addition, a method of producing sialylated protein in a plant is also provided. The method of synthesizing sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more of an epimerase, CMP-Neu5Ac synthase, a CMP-Neu5Ac transporter, and a sialyl transferase. |