http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-PI0704028-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5e48e11f0ae2a45f5f38bccdfaba54fa |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-16 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0095 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L29-256 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-715 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 |
| filingDate | 2007-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ee01f70676873eccaf83651aea78e11 |
| publicationDate | 2021-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-PI0704028-B1 |
| titleOfInvention | antacid pharmaceutical composition in powder form for rapid and prolonged neutralization of gastric acidity, pharmaceutical preparation in powder form and procedure for preparing the composition |
| abstract | antacid pharmaceutical composition in powder form for rapid and prolonged neutralization of gastric acidity, pharmaceutical preparation in powder form and procedure for preparing the composition. antacid pharmaceutical composition in powder form for the rapid and prolonged neutralization of gastric acidity with mucosal protective activity, intended to prepare by dispersion in water a pharmaceutical solution or suspension for oral use, where the composition comprises: sodium alginate, an antacid agent soluble or a combination of antacids, a proton pump inhibitor, and diluent and sweetening agents; where: (a) at least 30% of the sodium alginate present in the formulation together with the total proton pump inhibitor are homogeneously distributed on the surface of the total soluble antacid agent or combination of antacids in the composition; and (b) the rest, approximately 70%, of the sodium alginate present in the formulation contains a percentage of moisture below 2%. an elaboration process comprising (a) mixing the totality of the soluble antacid agent or combination of antacids in the composition, the total proton pump inhibitor and up to 30% of the sodium alginate in the composition until the mixture is homogeneous at room temperature in one convenient granulator; (b) impregnating the mixture of such components with water in the same granulator incorporating a total weight of water not exceeding 10% of the total weight of the total pharmaceutical composition; (c) dry the mixture thus obtained with normal pressure, vacuum or fluid bed with a temperature below 50ºc until a residual humidity of less than 2% is obtained; (d) incorporate into the granulate obtained in step (c) above, the rest of the sodium alginate of the composition and components of the formula also sieved and with a humidity of less than 2% and mix for 30 minutes; (e) check that the residual moisture in the composition is less than 2%, preferably less than 0.7%, and finally dosing and packaging. In this way, the wet granulation of the proton pump inhibitor with all the antacid agent or agents of the composition, other components and up to 30% of the alginate in the composition allows to achieve greater stability of the proton pump inhibitor through the homogeneous distribution of that inhibitor and part of the alginate of the composition on the surface of the antacid agent. the subsequent mixing with up to 70% of the sodium alginate present in the formulation and other components of the same would favor the rapid dispersion of the rest of the sodium alginate in the composition and would quickly increase the viscosity of the solution or suspension by mixing the composition with water before ingesting a rapid formation of a homogeneous suspension of all components of the composition after its reconstitution with water or another drink. preferably, this reconstitution is carried out in less than 2 minutes. |
| priorityDate | 2006-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 88.