| abstract |
OLIGORRIBONUCLEOTIDE FOR STIMULATING PRODUCT OF A PROFLAMMATIVE CYTOKINE, USE OF THE SAME AND COMPOSITION CONTAINING SUCH OLIGORRIBONUCLEOID. The invention provides immunostimulatory compositions and the use of such compounds in the preparation of medicaments for treating diseases as well as for in vitro uses. In particular, the compositions of the invention include immunostimulatory oligoribonucleotides that incorporate a sequence-dependent immunostimulatory sequence motif. Specific modifications involving phosphate bonds, nucleotide analogs, adducts, and combinations thereof are provided. The compositions of the invention, which may optionally include an antigen, may be used alone or in conjunction with other treatments to stimulate or enhance an immune response. Also provided are compositions and methods useful for treating an individual who has an infection, a cancer, an allergic condition, asthma, airway remodeling, or immunodeficiency. The oligoribonucleotides of the invention are believed to stimulate the "tolI" -like receptor 8 (TLR8). |