| abstract |
COMPOUND, PHARMACEUTICAL COMPOSITION, AND, IMBED TYROSIN KINASE Disclosed herein are compounds that form covalent bonds with Bruton's tyrosine kinase (Btk). Also described are irreversible Btk inhibitors. Methods for preparing the compounds are disclosed. Also disclosed are pharmaceutical compositions including the compounds. Methods of using Btk inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. |