| abstract |
Heterocyclic compounds. The present invention relates to novel heterocyclic compounds of general formula (1), their derivatives, analogs, tautomeric forms, stereoisomers, polymorph organisms, hydrates, solvates, salts and pharmaceutically acceptable compositions and compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel heterocycles of the general formula (1). Also included is a method for treating immune diseases, pain, rheumatoid arthritis; osteoporosis; multiple myeloma; uveitis; acute and chronic myeloid leukemia; ischemic heart disease, arteriosclerosis, cancer, ischemia-induced cell damage, pancreatic <225> cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis, anaphylaxis; contact dermatitis; muscle degeneration; cachexia; asthma; bone resorption diseases; ischemic reperfusion injury; head trauma; multiple sclerosis; sepsis; septic shock; toxic shock syndrome; fever and myalgia resulting from infection in a mammal, including administration of an effective amount of the compound of formula (1) as described above. |