| abstract |
USE OF A PHARMACEUTICAL COMPOSITION, PHARMACEUTICAL COMPOSITION, AND ANTIBACTERIAL AND ANTIGUTIC DISTRIBUTION SYSTEM. A pharmaceutical composition comprises (a) an antibacterial agent in an antibacterially effective amount, which illustratively comprises clindamycin or a pharmaceutically acceptable salt or ester thereof; and (b) an antifungal agent in an antifungal effective amount, which illustratively comprises butoconazole or a pharmaceutically acceptable salt or ester thereof. The composition is adapted for application in a unit dose amount to a vulvovaginal surface and has at least one non-lipoid internal phase and at least one lipoid external phase that is bioadhesive to the vulvovaginal surface. The composition is suitable for administration to a vulvovaginal surface to treat a bacterial vaginosis infection and mixed vulvovaginal candicliasis infection. |