| abstract |
IMIDAZO [1,2-a] PYRIDIN-3-IL-ACETIC ACID HYDRAZIDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL USES OF THE SAME. The present invention relates to novel imidazo [1,2-a] pyridin-3-yl acetic acid hydrazides of formula (I) wherein R 1, R 2 and R 3 have different meanings, and pharmaceutically acceptable salts, polymorphs, hydrates, tautomers, solvates and stereoisomers thereof. Compounds of formula (1) are useful for treating or preventing, in a human or nonhuman mammal, diseases associated with GABA-Aβ receptor modulation, anxiety, epilepsy, sleep disorders, including insomnia, and for inducing hypnosis by sedation, anesthesia, sleep and muscle relaxation. The invention also provides synthetic processes for preparing said compounds. |