http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-PI0620695-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69ece09bafee7e0c49d1f7951a3faa2c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-112 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-118 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-136 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57407 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2006-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4af61eeb9b1e4ede7112e88a33cc9afe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8cfd8abe2c06f505bb68de4c8a3b8763 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80eddb694e1ed06011a26c1779a8d26a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09183ababaacc8aa68e766bb4cb5abc0 |
| publicationDate | 2011-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-PI0620695-A2 |
| titleOfInvention | method for treating a glioma-like tumor, glioma prognosis and / or diagnosis methods, monitoring or diagnostic method, method for inhibiting the size or growth of a glioma-like tumor, methods for therapeutically treating, method for determining the level of expression of pn, prolif or mes glioma determinants ("gdm"), method for predicting survival time, method for diagnosing the severity of a glioma-like tumor and use |
| abstract | METHOD FOR TREATING A GLIOMA TYPE, METHODS OF PROGNOSIS AND / OR DIAGNOSIS OF GLIOMA, METHOD OF MONITORING OR DIAGNOSIS, METHOD OF INHIBITING THE GROWTH OR GROWTH OF A TUMOR OF THE TYPE OF GLYOMA, THERAPEUT, EXPRESSION OF GLIOMA DETERMINANT MARKERS ("GDM") OF PN, PROLIFED MONTHS, METHOD FOR PROGNOSING SURVIVAL TIME, METHOD FOR DIAGNOSING THE SEVERITY OF A TYPE OF THE GLYOMA TYPE AND USE. The invention in general provides a method of monitoring diagnosis, prognosis and treatment of glioma. Specifically, the invention establishes three (3) prognostic subcies of glioma, which are differently associated with the activation of the akt and Notch signaling pathways. Tumor showing markers of neural or proneural PN lineage (including elements of the notch pathway) shows longest patient survival mean, while the two remaining tumor markers Prolif and Mes are associated with short survival. Tumors classified in this way can also be treated with PN Prolif or Mes therapies that correspond to subclassification, in combination with anti-mitotic agents, anti-angiogenic agents, Akt antagonists and neural differentiation agents. Alternatively, the invention also establishes a method of prognosis and diagnosis of glioma with a double gene model based on the levels of expression of PTEN and DLL3. |
| priorityDate | 2005-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 670.