abstract |
CCR9 ACTIVITY INHIBITORS. The present invention relates to compounds of formula 1, one of which R ~ 1 ~ and R ~ 2 ~ is thienyl, which is substituted by halogen, and the other of R ~ 1 ~ and R ~ 2 ~ is replaced by phenyl, wherein the substituents are as defined in the claims, with the proviso that the phenyl group is replaced by at least one cyano, carboxy or (C ~ 1-4 ~) - alkoxycarbonyl group, which are inhibitors of CCR9 activity and useful for therapeutic treatment. |