| abstract |
AMINE COMPOUND AND USE OF THE SAME FOR MEDICAL PURPOSES. The present invention relates to a new amine compound represented by the following formula (I), where R is a hydrogen atom or P (= O) (OH) 2, X is an oxygen atom or a sulfur atom , Y is CH2 CH2 or CH = CH, R1 is cyano or alkyl having a carbon number from 1 to 4 and replaced by one or more halogen atoms, R2 is alkyl having a carbon number from 1 to 4 and optionally substituted by one or more hydroxyl groups or one or more halogen atoms, R3 and R4 can be the same or different and each is a hydrogen or alkyl atom having a carbon number from 1 to 4, and n is 5 to 8, which it is superior in immunosuppressive action, rejection suppressive action and the like, and has reduced side effects such as bradycardia and the like, or a pharmaceutically acceptable acid addition salt of the same, or hydrates of the same, or solvate, as well as a pharmaceutical composition containing this compound is a pharmaceutically acceptable carrier. |