| abstract |
OXADIAZOL DERIVATIVES WITH ACTIVITY IN THE CTRH ~ 2 ~ RECEPTOR, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM AND USE OF THE DERIVED REFERENCES. The present invention relates to compounds of formula (i) which are CRTH ~ 2 ~ binders, useful in the treatment of diseases inflammatory, autoimmune, respiratory or allergic: where R ~ 1 ~ is hydrogen or methyl and R ~ 2 ~ is optionally substituted cycloalkyl or optionally substituted non-aromatic heterocyclyl having 4 to 6 ring atoms; or R ~ 1 ~ and R ~ 2 ~, obtained together with the carbon atom to which they are attached form an optionally substituted cycloalkyl ring or optionally substituted non-aromatic heterocyclyl having 4 to 6 ring atoms; R is hydrogen or an optional substituent; the phenyl ring containing the substituent R being optionally substituted by 1, 2 or 3 optional substituents; A is hydrogen or C ~ 1 ~ -C ~ 3 ~ alkyl; the Ar ring is a 5- or 6-element optionally substituted monocyclic phenyl or heteroaryl ring. |