| abstract |
NANOEMULSION, PHARMACEUTICAL COMPOSITION, AND METHODS OF ADMINISTRATION OF BOTULIN TOXIN TRANSDERMICALLY TO AN INDIVIDUAL, TREATMENT OF, AND DELAYING THE BEGINNING OF WRINKLES, FACIAL LINES AND NURSES OF THE FISCAN The embodiment described herein relates to nanoemulsions comprising botulinum toxins. In one embodiment, the nanoemulsions are prepared by high pressure microfluidization and comprise a particle size distribution exclusively between 10 and 300 nm. The nanoemulsions contemplated by the present invention are useful for the cosmetic and medical treatment of muscle contracture conditions. For example, botulinum toxin can relax facial muscles so that skin wrinkles become smoother and less noticeable. In addition, the present invention contemplates a cosmetic formulation which may be self-administered, for example, in the privacy of the home and without medical supervision. |