| abstract |
COMPOUND, PHARMACEUTICAL COMPOSITION AND USE OF A COMPOUND. The invention encompasses new compounds of Formula (I) or their pharmaceutically acceptable salts. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 enzyme (mPGES-1) and are therefore useful for treating pain and / or inflammation of a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic. Also covered are methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions. |