| abstract |
COMPOSITIONS OF LIPOXYGENASE INHIBITORS. The present invention relates to pharmaceutical compositions comprising particles of lipoxygenase inhibitor compound having an effective average size of about 10 nm to about 50 microns. More particularly, it relates to particle pharmaceutical compositions of a 5-lipoxygenase inhibitor compound having an average effective size of about 50 nm to about 5 microns. The pharmaceutical compositions are in the form of aqueous suspensions with the particle of the 5-lipoxygenase inhibiting compound present in concentrations of about 5 to about 200 mg / ml. In addition, methods for producing such pharmaceutical compositions are provided. In particular, microprecipitation and direct homogenization in the presence of at least one surfactant are described for the production of the pharmaceutical compositions. |