| abstract |
USEFUL THERAPY COMPOUNDS, PHARMACEUTICAL FORMULATION CONTAINING THEM, AND THEIR USES. Compounds of formula (I), or a pharmaceutically acceptable derivative thereof, wherein R 13 and R 3 independently represent H, C 1-6 alkyl, C 3-8 cycloalkyl, or halogen; R 2 represents C 1-6 alkyl, CF 3 or aryl; a represents 1 or 2; R 4, R 5, R 7 and R 8 independently represent H, C 1-6 alkyl, C 1-6 alkyloxy, CN or halogen, or R 4 and R 4 R 5, or R 7 and R 8 together with the ring to which they are attached form an aryl or heterocyclic fused ring system; X represents C or N; Y represents CH 2 - 2 or O; R 6 represents H, CN or halo, but when X represents N then R 6 represents H; may be useful for the treatment of endometriosis, uterine fibroids (leiomyomata), menorrhagia, adenomyosis, primary and secondary dysmenorrhea (including symptoms of dyspareunia, dyschezia and chronic pelvic pain), or chronic pelvic pain syndrome. |