| abstract |
REPLACED BENZIMIDAZOLES AS KINASE INHIBITORS. The present invention relates to novel substituted benzimidazole compounds of formula (1), compositions and methods of inhibiting kinase activity associated with tumorigenesis in a human or animal subject. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The novel compounds and compositions can be used either alone or in combination with at least one additional agent for the treatment of a disorder mediated by serine/threonine kinase or receptor tyrosine kinase, such as cancer. |