| abstract |
PROCESS FOR PREPARING A COMPOUND, COMPOUND, RADIO-PHARMACEUTICAL KIT, AND CARTRIDGE FOR A RADIO-PHARMACEUTICAL KIT. The invention relates to a process for the preparation of a compound of formula (I): R 1 is selected from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl; comprising: (i) reaction with fluoride, suitably fluoride [18F], of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10alkyl, C1-10haloalkyl, C6-14aryl, C6- Arylalkyl, - (CH 2 CH 2 O) q -CH 3 wherein q is an integer from 1 to 10; R1 is as defined for the compound of formula (I); and R3 is a leaving group. Certain new precursors of formula (II) and radiopharmaceutical kits containing such precursors are also claimed. |