| abstract |
NF-KAPPAB HETEROCYCLIC INHIBITING COMPOUNDS, USE OF THE SAME AND PHARMACEUTICAL COMPOSITION. The present invention relates to compounds of the general formula (III) or pharmaceutically acceptable salts thereof with an acid or a base, or pharmaceutically acceptable prodrugs, or a stereoisomer thereof, wherein R3 is H, - C (O) NR ^ a ^ R ^ b ^, halogen, alkyl, haloalkyl, aryl, heteroaryl, OH, SH, NR ^ 4 '^ 0R ^ 5' ^, NH ~ 2 ~, amine, alkylamine, alkoxy, cycloalkyl , heterocycloalkyl, hydroxyalkyl, or haloalkyloxy; R ^ 4 ^ is H, halogen, alkyl, -C (NR ^ 7 ^) NR ^ 7 ^ R ^ 8 ^, - (CH2) p-aria, - (CH ~ 2 ~) NR ^ 7 ^ R ^ 8 ^, -C (0) NR ^ 7 ^ R ^ 8 ^, -N = CR ^ 7 ^ R ^ 8 ^, -NR ^ 7 ^ C (O) R ^ 8 ^, cycloalkyl, heterocycloalkyl, haloalkyl, hydroxyalkyl, hydroxyalkylamino, alkylamino, heteroaryl, or aryl; R ^ 5 ^ is halogen, alkyl, -C (NR ^ 7 ^) NR ^ 7 '^ R ^ 8 ^, - (CH ~ 2 ~) p-ary, - (CH ~ 2 ~) pNR ^ 7 ^ R ^ 8 ^, -C (O) NR ^ 7 ^ R ^ 8 ^, -N = CR ^ 7 ^ R ^ 8 ^, -NR ^ 7 ^ C (O) R ^ 8 ^, cycloalkyl, heterocycloalkyl, haloalkyl, hydroxyalkyl, hydroxyalkylamino, alkylamino, heteroariIa, or aryl. |