abstract |
MACROCYCLIC INHIBITORS OF HEPATITIS C AND PHARMACEUTICAL COMPOSITION CONTAINING THEM. The present invention relates to compounds of formula (1): and N-oxides, salts, and stereoisomers thereof wherein A is O R 1, NHS (O) R 2 R 2; on what; R4 is hydrogen, C1 -C6 alkyl, C1 -C3 alkylenecarbocyclyl, C1 -C3 alkylene heterocyclyl; R 2 is C 1 -C 6 -alkyl, C 0 -C 3 alkylenecarbocyclyl, C 0 -C 3 alkylene heterocyclyl; p is independently 1 or 2; n is 3, 4, 5 or 6; deonotes an optional double bond; L is N or GRz; Rz is H or forms a double carbon bond with asteric; Rq is H or when L is CRz, Rq may likewise be C-1-G6alkyl, Rr is quinazolinyl, optionally substituted with one or three substituents each independently selected from C1-C2. 6-alkyl, C1-C6-alkoxy, hydroxyl, halo, halo-C1-C6-alkyl, amino, mono- or dialkylamino, mono- or dialkylaminocarbonyl, C1-C6 alkylcarbonylamino, C 0 -C 3 alkylene carbocyclyl and O C 3 alkylene heterocyclyl; R5 is hydrogen, C1 -C6 alkyl, C1 -C6 alkoxyC1-6 alkyl or C3 -C7 cycloalkyl; R 6 is hydrogen, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 0 -C 3 alkylenecarbocyclyl, C 0 -C 3 alkylene heterocyclyl Hydroxy, bromine, chlorine or fluorine have utility in the treatment or prophylaxis of flaviviral infections such as HOV. |