| abstract |
INHIBITION OF OSTEOLYTIC INJURIES BY SRC KINASE INHIBITORS. The present invention includes methods and compositions for treating bone resorption diseases or bone resorption related to a pathological condition including, but not limited to, osteoporosis, arthritis, rheumatoid arthritis, bone cancer metastasis, bone cancer, hypercalcemia, osteolytic lesions with orthopedic implants, Paget's disease, and bone loss associated with hyperparathyroidism. Representative cancers include, but are not limited to, breast cancer, prostate cancer, colon cancer, endometrial cancer, multiple myeloma, renal cell carcinoma, Heck's disease, neck and head cancers, and cervical carcinoma. Arthritic conditions include, but are not limited to, adjuvant-induced arthritis, collagen, bacteria and antigen, particularly rheumatoid arthritis. |