| abstract |
COMPOUND, PHARMACEUTICAL COMPOSITION, AND METHOD FOR MANUFACTURING A MEDICINAL PRODUCT. It is intended to provide a compound represented by formula (I). (wherein R represents an alkyl group having 1 to 6 carbon atoms substituted with 2 hydroxyl groups, Cy represents a bicyclic or tricyclic aliphatic carbocyclic group having 6 to 10 carbon atoms which may have a substituent in some cases). The compound acts as a nociceptin receptor antagonist and is useful as, for example, a narcotic analgesic resistance reversing agent; a reverse agent for narcotic analgesic dependence or withdrawal syndrome; an intensifying agent of analgesic action; an anti-obesity agent or an appetite control agent; an enhancer or preventive agent for decline in memory and learning abilities or dementia symptom; an enhancer for cognitive function at the developmental stage; a therapeutic agent for schizophrenia; a therapeutic agent for regressive neurodegenerative disease; an antidepressant agent or an emotion control agent; a therapeutic agent or preventive agent for diabetes insipidus; a therapeutic agent or preventive agent for polyuria; a therapeutic agent for hypopiesis and the like. |