| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3386f5906dc1bdc9c934203594712c66 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-445
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4545
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4525
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate |
2006-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e40a2f454cc686dbc3f04868c0f1bd1c |
| publicationDate |
2010-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
BR-PI0612928-A2 |
| titleOfInvention |
METHOD FOR INCREASING THE ACTIVITY OF AN (ALPHA) -GLUCOSITY ENZYME IN A CELL AND METHOD FOR TREATING POMPE'S DISEASE |
| abstract |
PAPA METHOD TO INCREASE ACTIVITY OF A <244> -GLUCOSIDASE ENZYME IN A CELL AND METHOD FOR TREATING POMPE DISEASE. The present invention provides a method for enhancing the activity of a mutant or wild type β-glycosidase enzyme in vitro and in vivo by contacting the enzyme with a specific pharmacological chaperone which is a 1-deoxinojirimycin derivative. The invention also provides a method for the treatment of Pompe's disease by administering a small-molecule plaqueerone compound which is a 1-deoxinojirimycin derivative. The 1-deoxinojirimycin derivative is substituted at the N or C1 position. Combination therapy with β-glycosidase gene or enzyme substitution is also provided. |
| priorityDate |
2005-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |