| abstract |
PROCESS TO PREPARE A COMPOUND. The present invention provides novel processes for the preparation of substituted and unsubstituted 4-amino-2- (2,6-dioxo-piperidin-3-yl) -isoindoline-1,3-dione compounds which are useful, for example, to prevent or treat diseases and conditions related to an abnormally high level or activity of TNF-a. The invention may provide improved and / or efficient processes for the commercial production of substituted or unsubstituted 4-amino-2- (2,6-dioxo-piperidin-3-yl) -isoindoline-1,3-dione compounds, including but not limited to unsubstituted 4-amino-2- (2,6-dioxo-piperidin-3-yl) -isoindoline-1,3-dione. |