| abstract |
ORAL DOSAGE FORM UNDERSTANDING AN INDEPENDENT ANTI-USE SYSTEM. An oral solid dosage form containing one or more active ingredients having analgesic properties, the dosage form composition being such as to prevent misuse of the dosage form by liquid extraction of the active ingredient (s). ) contained therein, using commonly available solvents. The oral solid dosage form containing at least one salt of at least one analgesic active ingredient and an anti-misuse system comprising at least one extinguishing agent, the extinguishing agent being suitable for inducing analgesic active ingredient salt complexation when the analgesic active ingredient salt is extracted inappropriately, notably by a drug user, in in vitro solution from the oral solid dosage form. |