| abstract |
Aminopyrimidines as kinase modulators. The invention relates to aminopyrimidine compounds of formula I: where R 3 -, 6, Z, Q, p, and R 1 - are as defined herein, the use of these compounds as protein tyrosine kinase modulators, particularly FLT3 and / or c-kit and / or TrkB inhibitors, the use of these compounds to reduce or inhibit FLT3 and / or c-kit and / or TrkB kinase activity in a cell or an individual, and the use of these compounds. compounds for preventing or treating in a subject cell proliferative disorder and / or FLT3 and / or c-kit and / or TrkB-related disorders. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention and methods for treating conditions such as cancers and other cell proliferative disorders. |