| abstract |
Stable and soluble antibodies that inhibit TNFALFA. The present invention relates to particularly stable and soluble TNF? Specific scFv antibodies and Fab fragments, which comprise specific light chain and heavy chain sequences, which are optimized for stability, solubility in vitro and in vivo binding, and low immunogenicity. Said antibodies are designed for the diagnosis and / or treatment of TNF? Nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also described. |