abstract |
FLUORENE DERIVATIVE PRODUCTS, MEDICINAL PRODUCTS AND COMPOSITIONS CONTAINING THEM, AND USE. The invention relates to novel products of formula (I): wherein A1, A2, A3 and A4 represent CRa or N; R1 and R1 'are such that one represents H, Hal, C1-C3-alkyl, C1-C3-alkoxy, alkyl-OH, CF3, damage, carboxy and boxamido; and the other represents H; HAL; CF3; OH; SH; nitro; amino; NH-OH; NH-CO-H; NH-CO-OH, NH-CO-Oalkyl, NH-CO-NH2; carboxy; CN; CO-NH 2; X- (CH 2) m -alkyl; X- (CH 2) m -cycloalkyl; X- (CH 2) m -heterocycloalkyl; X- (CH 2) m -aryl or X- (CH 2) m -heteroaryl with X = single bond, CH 2, CH = CH, CH 2 -O, CH 2 -NH, CH 2 -C (O), CH 2 -C ( O) -O, CH 2 -C (O) -NH, CH 2 -NH- (CO), CH 2 -NH-S (O), CH 2 -NH-S (O) 2, O, S, NH, OC (O ), C (O) -NH, -NH-C (O), -NH-C (O) -C (O) -, -NH-C (O) -NH-; NH-CS, NH-S (O) or NH-S (O) 2; with m = 0.1 or 2; R 1 and R 1 'form with O to which a radical = O is attached; = S; = N-OH; = N-NH 2; = N-NH-CO-NH 2; = CH-OH; = YI- (CH2) m -aryl or = Y1- (CH2) m -heteroaryl wherein Y1 represents CH, CH-CO-, CH-CO-NH, N, NO or N-NH- with m = 0.1 or 2, one cycle, R2 and R'2, represent H, halogen, CF3, nitro, cyano, alkyl, hydroxy, mercapto, amino, alkylamino, dialkylamino, alkoxy, alkylthio, free or esterified carboxy, carboxamide, CO-NH (alkyl) and CO N (alkyl) 2, p = 1 to 3 and p '= 1 to 4; Ra represents H; halogen; CF3; hydroxy; mercapto; nitro; amino; NH-OH; NH-CO-H; NH-CO-NH 2; carboxy; CN; CO-NH 2; Y- (CH 2) n -alkyl; Y- (CH 2) n -cycloalkyl, Y- (CH 2) n -hetero-cycloalkyl, Y- (CH 2) n -aryl or Y- (CH 2) n -heteroaryl with Y = O, S, NH, OC (O), C (O) -NH, NH-C (O), NH-S (O) or NH-S (O) 2, with n = 0, 1, 2, or 3, all alkyl radicals, optionally substituted alkoxy, alkylthio, cycloalkyl, heterocycloalkyl, aryl and heteroaryl, these products being in all tautomeric and isomeric forms and salts thereof, as medicaments. |