| abstract |
isolated human or humanized antibody, or a functional fragment thereof, isolated antigen-binding region of an antibody, or an antibody functional fragment, variable heavy chain, an isolated human or human antibody or a functional antibody fragment, isolated nucleic acid sequence; vector, isolated cell, pharmaceutical composition and method of treating a disorder or contention associated with the unwanted presence of gm-csf the present invention provides the recombinant antigen-binding regions, antibodies and functional fragments thereof that are specific to the gm-csf, which play an integral role in various disorders or conditions. these antibodies, therefore, can be used to treat, for example, inflammatory diseases such as rheumatoid arthritis. antibodies according to the present invention can also be used in the field of diagnosis, as well as to investigate also the role of gm-csf in the progression of various disorders. the present invention also provides the nucleic acid sequences encoding the foregoing antibodies, vectors containing them, pharmaceutical compositions and kits with instructions for use. |