| abstract |
METHOD FOR PREPARING A FORMULA COMPOUND (1); AND METHOD FOR PREPARING AN ACID OF FORMULA (VII) The present invention relates to a method for synthesizing compounds of formula (1) wherein X, Z, V, R 1, R 3, R 4, 02, n, x, y , and z are defined herein. This invention also includes a method for preparing acidic compounds of formula (VII) wherein R is H, and R 4, x, y, and z are as defined herein and PG is a protecting group. This invention also relates to (E) -N- {4- [3-chloro-4- (2-pyridinyl-methoxy) -anilino] -3-cyano-7-ethoxy-6-quinolinyl} -4- ( methyl-amino) -2-butenamide, compositions containing it, and methods for using them to treat cancer. |