| abstract |
TIAMINE DERIVATIVES. An unprecedented compound with strong EXa inhibiting potency and capable of excellent antithrombotic effect by oral administration is provided. Compounds of the general formula are provided: (1) wherein each R 1 and R 2 independently are a hydrogen atom, hydroxyl, an alkoxy or an alkoxy; Q¹ is an optionally substituted saturated or unsaturated bicyclic or tricyclic condensed hydrocarbon group or an optionally substituted saturated or unsaturated bicyclic or tricyclic condensed heterocyclic group, etc .; Q 2 is a single bond, a straight or branched C 1 -C 6 alkylene, a straight or branched C 2 -C 6 alkenylene, etc .; each of R3 and R4 is an alkyl, etc .; each of you and n is a number from 0 to 3; Q ^ 4 ^ is an aryl; and each of T40 and T40 is carbonyl, etc., and pharmaceutical products comprising any of the compounds are provided. |