| abstract |
DIAZA-ESPIRO- [4,4] -NONANO SUBSTITUTED DERIVATIVES AND ITS USE AS NEUROCININE ANTAGONISTS. The present invention relates to diaza-spiro [4.4] nonane derivatives having neurokinin antagonistic activity, in particular NK-1 antagonistic activity, its preparation, compositions comprising them and their use as a medicament, in particular for the treatment and / or prophylaxis of schizophrenia, emesis, anxiety and depression, irritable bowel syndrome (IBS), circadian rhythm disorders, preeclampsia, nociception, pain, in particular visceral and neuropathic pain, pancreatitis, neurogenic inflammation, asthma , chronic obstructive pulmonary disease (COPD) and urination disorders such as urinary incontinence. The compounds according to the invention may be represented by the general formula (1) and further comprise pharmaceutically acceptable acid or base addition salts thereof, stereochemically isomeric forms thereof, N-oxide form thereof and prodrugs thereof, wherein all substituents are as defined in claim 1. |