http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-PI0607874-A2
Outgoing Links
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|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dee814b1ba7fddffa2ecdea48bf074f4 |
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| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6806 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2006-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8562c8486744e3478ee3313d649e6d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01d7ee77eb8f5448a524cd3a0cdd93f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa321290df8caa7b8ac17760c9f0af64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2aeb082eb2549266542675be3fa4621c |
| publicationDate | 2009-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-PI0607874-A2 |
| titleOfInvention | Microarray and laser microdissection analyzes of breast tumors reveal estrogen receptor-related genes and pathways |
| abstract | MICROARRANGE ANALYSIS AND LASER MICRODISSECTION OF BREAST TUMORS REVEAL STROGEN RECEIVER-RELATED GENES AND ROUTE. About 70% to 80% of breast cancers express estrogen receptor <244> (ER <244>), and estrogens play important roles in the development and growth of hormone-dependent tumors. Along with lymph node metastasis, tumor size and histological grade, ER status is considered one of the prognostic factors in breast cancer, and an indicator for hormone treatment. 147 genes and 112 genes with significant P-value and which have significant differential expression between ER + and ER- tumors were identified from the LCM dataset and the bulk tissue dataset, respectively. 61 genes were considered common in both datasets, while 85 genes were unique to the LOM dataset and 51 genes were present only in the bulky tumor dataset. Analysis of pathways with 85 genes using Gene Ontology suggested that genes involved in endocytosis, ceramide generation, Ras / ERK / Ark cascade, and via JATSTAT may perform ER-related functions. Gene profiling with LCM-captured tumor cells provides a unique approach to characterize and study epithelial tumor cells and to gain insight into the signaling pathways associated with ER. |
| priorityDate | 2005-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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|---|---|
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6372196 http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID426100422 |
Total number of triples: 23.