| abstract |
ACTIVATION OF BACTERIAL NKT CELL GLYCOLIPIDE RESTRICTED TO CD1d. Methods for activating an NKT cell, methods of stimulating an immune response in an individual, methods of improving vaccine efficacy, and methods of treating an infection are disclosed. Also disclosed are methods for promoting tumor rejection, cancer treatment, autoimmunity modulation, and allergen-induced hypersensitivity inhibition in an individual. Methods include contacting an NKT cell with a bacterial glycolipid complexed with a CD1 molecule to activate the NKT cell. Bacterial glycolipid may be derived from a member of the Alphaproteo-bacteria Class. |