| abstract |
TETRAHYDROFURAN DERIVATIVES FOR USE AS MOTHER METALOPROTEINASES INHIBITORS. The present invention relates to compounds of formula (1) which are suitable for the manufacture of drugs for use in the prophylaxis and therapy of diseases which are associated with increased matrix metalloproteinase activity. Examples of such diseases are degenerative joint diseases, such as osteoarthritis, spondylosis, chondroprosis following joint trauma or prolonged joint immobilization after meniscal injury or patella rupture of a ligament or connective tissue disease such as collagen, periodontal disease, healing of defective injury or chronic disorders of the locomotor system, such as chronic, acute, immunologically or metabolically related inflammatory arthritis, arthropathies, myalgias or disorders of bone metabolism or an ulceration, atherosclerosis or stenosis or an inflammatory disease or a tumorigenic, metastatic spread tumor, cachexia, anorexia or septic shock. |