| abstract |
4- OR 5-AMINOOSALICYLIC ACID DERIVATIVES. The present invention relates to novel 4- or 5-aminosalicylic acid derivatives and a pharmaceutical composition containing such 4- or 5-aminosalicylic acid derivatives as the active ingredients useful for the treatment of intestinal diseases such as inflammatory disease. (IBD) and irritable bowel syndrome (IBS) and for the prevention / treatment of colon cancer. More specifically such derivatives comprise a hydrogen sulfide release moiety linked via an azo bond, an ester, an anhydride, a thioester or an amide bond to a 4- or 5-aminosalicylic acid molecule. In addition, the present invention provides a process for the preparation and use of such compounds for the treatment of IBD and IBS and the prevention and treatment of colon cancer. |