http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-PI0520520-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b00b136e60a05dcd135efb8d56409ef0 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L2430-06 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-363 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3817 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3852 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0012 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-50 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-32 |
| filingDate | 2005-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_789773c1ada927fd717789697933b1ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c499e48cca948822f5b905b4d0910789 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1871bf6bdf61a9524401005a4d3dfc4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f14a0139dfcb4a6922ee28f355994e9b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b2c8ccccc11152b3ecbdc251f372977 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_44e70f94998e8eb7c9d2c2042d98d708 |
| publicationDate | 2009-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-PI0520520-A2 |
| titleOfInvention | simple method of injectable chondrocyte transplantation for autologous chondrocyte transplantation |
| abstract | Simple Method of Injectable Chondrocyte Transplantation for Autologous Chondrocyte Transplantation. It comprises mixing matrix containing fibrin, hyaluronic acid and collagen, which are the main ingredients of animal cartilage, by using a front mixing tip of a syringe, while the resulting mixture is injected into an injured cartilaginous region. In addition, the present invention provides a method of injectable chondrocyte transplantation for autologous chondrocyte transplantation, comprising the following steps: placing 1 ml of a chondrocyte culture contained in Vial No. 1 (Red) into a sterile 1-liter syringe. ml and inject the cell culture into Vial No. 2 (Blue) containing white or light yellow lyophilized powder (fibrinogen) by inserting the syringe into Vial No. 2 vertically so that the fibrinogen concentration varies between 10 mg / ml and 200 mg / ml; Inject 1 ml of the cell culture contained in Vial No. 1 (Red) into Vial No. 3 (Red, small) containing white lyophilized powder (thrombin) by inserting the syringe into Vial No. 3 vertically by injecting thus gradually the red liquid; Collect 0.1 cc of the 1 ml contents of Vial No. 3 (Red, small) using a 1 ml syringe and then inject into the bottom of Vial No. 4 (Yellow) such that the thrombin concentration ranges from 1 IU / mI to 200 IU / mI; Add the entire contents of two vials containing the chondrocyte suspension to Vial No. 4 (Yellow) using a 1 ml sterile syringe and then mix the contents (two or three times) using the syringe; Confirm complete dissolution of the contents of Vial No. 2 (Blue) and then inject all dissolved material into a 1 ml syringe; Inject the well-mixed Cell Therapeutic Agent from Bottle 4 (Yellow) into a 1 ml syringe, and; Mount two 1 ml syringes filled with the contents of Vial No. 2 (Blue) and Vial No. 4 (Yellow) into a fixed holder, then mount a front mixing tip to the syringes and mix the contents of the syringes. , through the use of the front mixing tip, while the resulting mixture to be transplanted is injected into an injured cartilaginous region of an animal. The present invention with the aforementioned construction offers advantageous effects, such as, for example, solution to the inconveniences presented by conventional osteoperiosteal graft by mixing and transplanting fibrin, hyaluronic acid and collagen containing matrices, which are the main ingredients of cartilage. ; treating a wide variety of cartilage defects and severe osteoarthritis; relieving the suffering of patients to be treated through a simplified method of surgical operation, and; consequently promoting faster and more effective cartilage generation, which results in better patient satisfaction. |
| priorityDate | 2005-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.