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filingDate 2005-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a389cf7f28ea829d01bc6a67538bf2b
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publicationDate 2020-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber BR-PI0519476-B1
titleOfInvention process for cefaclor synthesis and process for obtaining cefaclor
abstract process for the synthesis of cefaclor the present invention relates to a process for the synthesis of cefaclor, a process which comprises reaction of 7-amino-3-chloro cephalosporanic acid (7-acca) with d-phenylglycine in activated form (pga) in the presence of an enzyme in a reaction mixture to form cefaclor, in which at least part of 7-acca and / or pga is added to the reaction mixture during the course of the reaction. the invention also relates to an aqueous mixture comprising an amount of cefaclor of> 10% (weight / weight), an amount of 7-amino-3-cephalosporanic acid of <2% (weight / weight) and an amount of d -phenylglycine <2% (weight / weight) and a process for the recovery of cefaclor from this aqueous mixture. the invention also relates to cefaclor in crystal form having an absorbance at 400 nm (at ~ 400 ~) of less than 0.250.
priorityDate 2004-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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