| abstract |
PHENYL-PIPERAZINE METHANONE DERIVATIVES. The present invention relates to compounds of general formula I wherein R¹ is the group R² is a non-aromatic heterocycle, or is N (R ") -2; R¹ is lower alkyl, halogen substituted lower alkyl or - (CH (2) -N-cycloalkyl; R "is lower alkyl; Rü is NO ~ 2 ~, CN or SO ~ 2 ~ R '; R4 is hydrogen, hydroxy, halogen, NO2-, lower alkyl, lower alkyl, substituted by halogen, lower alkoxy, SO2-2 R 'or C (O) OR "; 6 ^ / R ^ 7 ^ are hydrogen, halogen, lower alkyl or lower alkyl substituted by halogen; X¹ / X¹ are CH or N, provided that X¹ / X¹ are not simultaneously CH; X² is O, S, NH or N (lower alkyl), n is 0.1 or 2, and pharmaceutically active acid addition salts and their use in the treatment of neurological and neuropsychiatric disorders. |