| abstract |
SULFONIL BENZIMIDAZOL DERIVATIVES. This invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein A, B, R ', R' and R 'are each as described herein and compositions containing such compounds and the use of such compounds. in the treatment of a condition mediated by CB2 receptor activity such as, but not limited to, inflammatory pain, nociceptive pain, neuropathic pain, fibromyalgia, chronic lower back pain, visceral pain, acute cerebral ischemia pain, chronic pain, acute pain, neuralgia post herpetic, neuropathies, neuralgia, diabetic neuropathy, HIV-related neuropathy, nerve injury, rheumatoid arthritis pain, osteoarthritic pain, low back pain, cancer pain, dental pain, fibromyalgia, neuritis, sciatica, inflammation, neurodegenerative disease, cough, bronchial constriction, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), colitis, cerebrovascular ischemia, emesis such as chemotherapy-induced emesis rheumatoid arthritis, asthma, Crohn's disease, ulcerative colitis, asthma, dermatitis, recurrent allergic rhinitis, GERD, constipation, diarrhea, functional gastrointestinal disorders, irritable bowel syndrome, cutaneous T-cell lymphoma, multiple sclerosis, osteoarthritis, psoriasis, systemic lupus erythematosus, diabetes, glaucoma, osteoporosis, glomerulonephritis, renal ischemia, nephritis, hepatitis, brain attack, vasculitis, myocardial infarction, cerebral ischemia, reversible airway syndrome, COPD, cryptogenic fibrous alveolitis and bronchitis . |