| abstract |
"CARBO AND HETEROCYCLIC ANTIBIOTICS AND USE OF THE SAME". The present invention relates to compounds of formula (1.0); and pharmaceutically acceptable salts of such compounds. The present invention relates to chemical entities containing a nitrofuran or other antibiotic linked to a distal ring enhancing activity system directly or via an imine group, vinyl group, carbo or heterocyclic chain or ring or a combination of an imine group. or a vinyl group and a carbo or heterocyclic chain or ring. Antibiotic activity is obtained, for example, by the nitrofuran moiety, while the remaining structure of the molecule contributes to additional antimicrobial activity and / or extends the antimicrobial spectrum of activity by facilitating nitro-reduction by microorganisms, retention in target bacteria, and / or intracellular penetration, while also contributing to pharmacological properties (absorption, distribution in the body and others). |