| abstract |
15BE-SUBSTITUTED STEROID COMPOUND, PHARMACEUTICAL COMPOSITION, AND USE OF A COMPOUND The invention provides 15ß-substituted steroidal compounds that have selective estrogen receptor activity according to Formula (1) wherein, R¬ ¹¬ is H, C ~ 1-5-alkyl, C-1-12-water, di- (C-1-3-alkyl) aminocarbonyl, (C-1-5-alkyl) oxycarbonyl or sulfamoyl, R¬² is H, C-- 1-3-alkyl, C-2-3-alkenyl or C-2-3-alkynyl, each of which may be optionally substituted with a halogen, R¬ ³¬ is C-1-2-alkyl, ethenyl or ethinyl each of which may optionally be substituted with a halogen and R¬4¬ is H or C1-12-12 acyl. |