| abstract |
TREATMENT OF INFLAMMATORY DISORDERS AND PAIN Compounds that may be used for the treatment or prevention of a condition associated with T cell proliferation or which is mediated by proinflammatory cytokines, wherein the compound is of formula (I) is CHR ~ 4 -OR ~ 5 ~ or CHR ~ 4 ~ -SR ~ 5 ~ or aryl or heteroaryl optionally substituted with one or more R 6 - groups; R 2 is alkyl or part of a ring with R 3; R 3 is H, alkyl or CH 2 (when it is part of a ring with R 2); R 4 is H, alkyl or is part of a ring with R 5; R5 is aryl or heteroaryl optionally substituted with R7; R6 is independently alkyl, CF3, OH, Oalkyl, OCOalkyl, CONH2, CN, halogen, NH2, NO2, NHCHO, NHCONH2, NMSO2 alkyl. , CONH ~ 2- ~, SOMe, SO ~ 2 ~ NH ~ 2 ~, Salquila, CH ~ 2 ~ SO ~ 2-alkyl or OGONalkyl ~ 2 ~; R ~ 7 ~ is R ~ 8 ~ or (CH ~ 2 ~) nOR ~ 8 ~, R ~ 9, CF ~ 3 ~, OH, OR ~ 9 ~, OCC ~ 9 ~, COLOR ~ 9 ~, COOR ~ 9 ~, CONH ~ 2 ~, CH ~ 2 ~ CONH ~ 2 ~, CN, halogen, NH ~ 2 ~, NO ~ 2 ~, NHCHO, NHCONH ~ 2 ~, NHCONHR, NHCON (R ~ 9 ~) ~ 2 ~, NHCOR ~ 9 ~, NHCOaryl, NHSO ~ 2 ~ Me, CONH ~ 2 ~, SMe, SOMe or SO ~ 2 ~ NH ~ 2 ~; R ~ 8 ~ is (CH ~ 2 ~) ~ n ~ OR ~ 9 ~, (CH) nOR ~ 9 ~, (CH ~ 2 ~) nCOOR ~ 9 ~ or (CH ~ 2 ~) nCOaryl; R 9 is alkyl or cycloalkyl; and n is 1 to 4; or a salt thereof. |