| titleOfInvention |
compound or a pharmaceutically acceptable salt, solvate or hydrate thereof, pharmaceutical composition, and methods for inhibiting angiogenesis, for inhibiting or reducing tubulin polymerization or tubulin stability in a cell, for inhibiting pde4 activity in a cell , to inhibit tumor necrosis factor-alpha (tnf-alpha) activity in a cell, to treat or ameliorate an inflammatory disorder, to treat or ameliorate cancer, to inhibit cancer cell proliferation, to mark, block or destroy Tumor vasculature function, to tag, block or destroy tumor vessel endothelium, to tag, block or destroy tumor vasculature function and inhibit angiogenesis in a tumor, and to treat or ameliorate a central nervous system disorder |
| abstract |
COMPOUND OR A PHARMACEUTICALLY ACCEPTABLE SALT, SOLVATOR OR HYDRATE OF THE SAME, PHARMACEUTICAL COMPOSITION, AND METHODS TO INHIBIT ANGIOGENESIS, TO INHIBIT OR REDUCE TUBULIN AUBULITY IN THE CUBULA TUBULITY OR IN A CUBULA TUBULITY A , TO INHIBIT THE ACTIVITY OF THE TUMOR NECROSIS ALPHA FACTOR (TNF-ALPHA) IN A CELL, TO TREAT OR IMPROVE AN INFLAMMATORY DISORDER, TO TREAT OR IMPROVE CANCER, BRANCHARUS OR CELL, CANCEROSA CELL, PROLIFERATION THE FUNCTION OF TUMOR VASCULATURE TO MARK, BLOCK OR DESTROY TUMOR VASE ENDOTHELIUM TO MARK, BLOCK OR DESTROY TUMOR VASCULATURE AND INHIBIT ANGIOGESIS IN A TUMOR BETTER NURISM The present invention relates to Diphenylethylene Compounds and compositions comprising a Diphenylethylene Compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a patient in need thereof one or more Diphenylethylene Compounds. In particular, the invention relates to methods for preventing or treating cancer or an inflammatory disorder by administering to a patient in need thereof one or more Diphenylethylene Compounds. The present invention further relates to articles of manufacture and kits comprising one or more Diphenylethylene Compounds. |