http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-PI0513024-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_29afd7c50641eac715f32c9f2e39b998 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-6037 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-141111 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0013 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-542 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-643 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-1282 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-385 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-646 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 2005-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a532ef74c982e5e25b7a3bdaa7e77151 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d1064b47f1a494971ca9fb3c32f63cd |
| publicationDate | 2008-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-PI0513024-A |
| titleOfInvention | process for the preparation and use of a bivalent morphine heroin addiction vaccine |
| abstract | PROCESS FOR PREPARING AND USING A BIVALENT VACCINE AGAINST MORPHINE-HEROIN ADDICTION. The present invention relates to a structural design, preparative methods and chemical composition of two structural formulations of bivalent morphine-heroin addiction vaccines (tetanus morphine-6-hemissuccinyl-EDC-TFCS-toxoid and 3-O-carboxymethylmorphine). EDC-TFCS-tetanus toxoid). These vaccines are suitable for human use where they are capable of triggering synthesis of polyclonal antibodies against morphine opiate and its structural analog, heroin, through repeated in vivo administration of these formulations, in active vaccination protocols, in preclinical studies in rodents. . The active vaccination paradigm whereby these immunogens trigger a humoral immune response consolidated with long-term immunological memory characterized by the presence of high specific antibody titers against these two drugs of abuse is also described. Further, the present invention discloses the efficacy of such conjugate formulations for triggering sustained immunoprotection against morphine and heroin addiction using a paradigm of intravenous self-administration of these opiate rodent substances thereof. Finally, a discussion is also held on the potential future use of these immunoconjugates in active vaccination protocols for the treatment of both morphine and heroin addiction in humans. |
| priorityDate | 2004-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.