| abstract |
AZA-SUGAR DERIVATIVES, HEPARANASE INHIBITORS, THEIR PREPARATION PROCESS, THE COMPOSITIONS CONTAINING THEM, THEIR USE. The present invention relates to heparanase inhibiting compounds, corresponding to the general formula (I): wherein: R represents a hydrogen atom, a hydroxyl radical, a -OSO-3 ~ radical, a -O- (C ~) radical. 1 -C 5 - alkyl or an -O-aralkyl radical; Z represents a COO- or hydroxyl radical, X represents -OH or a saccharide unit of formula A; Y represents H, (C 1 -C 5 -C) alkyl or a saccharide unit of formula D; in free form or in the form of salts formed with a pharmaceutically acceptable base or acid, as well as in the form of solvates or hydrates. Medicines. |