| abstract |
The present invention relates to novel compounds of the 2-propen-1-ones series of formula (1), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs. pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them, wherein R 5, R 6, Q and Y are as defined in the report. The present invention also relates to a process for the preparation of such compounds, compositions containing such compounds and the use of such compound and composition in medicine. The compounds of general formula (1) induce HSP-70 and are useful for the treatment of diseases that accompany pathological stress in a living mammalian organism, including a human being, such as stroke, myocardial infarction, inflammatory disorder, hepatotoxicity, sepsis, viral disease, allograft rejection, tumor disease, gastric mucosa damage, cerebral hemorrhage, endothelial dysfunction, diabetic complications, neurodegenerative disease, neuronal post-traumatic damage, acute renal failure, glaucoma, and related skin degeneration. aging. |