abstract |
antibodies and molecules derived from them that bind to steap-1 proteins. The present invention relates to antibodies and molecules derived therefrom which bind to the novel steap-1 protein, and variants thereof, wherein steap-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the present invention. cancers listed in table i. consequently, steap-1 provides a diagnostic, prognostic, prophylactic and / or therapeutic target for cancer. the steap-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, may be used to elicit a humoral or cellular immune response; Steap-1 antibodies or t-reactive t cells may be used for active or passive immunization. |