http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BR-PI0418420-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_845d73285f7291be5a67cb38d9f2c6d6 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2800-57 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4732 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K6-838 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-64 |
| filingDate | 2004-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52991beff81cdaca8534d52092d80d00 |
| publicationDate | 2007-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BR-PI0418420-A |
| titleOfInvention | anticariogenic proteins, peptides and saccharides |
| abstract | ANTICARIOGENIC PROTEINS, PEPTIDES AND SACARIDS. The present invention relates to novel proteins, peptides and saccharides which have anticaryogenic ability and which are characterized by the presence of one or more components which have the ability to form a calcium ion complex: such as epsilon-polylysine which is conjugated to a or more bisphosphonyl, biscarboxyl or 3-hydroxyflalate groups or conjugated with casein phosphopeptide, phosvitine or partially hydrolyzed fosvitine; such as partially hydrolyzed chitosan which is conjugated to one or more bisphosphonyl groups, casein phosphopeptide or to partially hydrolyzed phosvitine or fosvitine; such as bisphosphonylated and biscarboxylated proteins having at least 40% of amino acids consisting of lysine and a molecular weight above 2 KD (2,000 Dalton) and such as polymerized casein phosphopeptide and partially hydrolyzed phosvitine. Especially basic polymers that are conjugated with bisphosphonyl groups such as bisphosphonylated epsilon-polylysine are strong protectors due to the simultaneous presence in a calcium complexing molecule and strong acid buffer components. In addition, polylysines such as epsilon-polylysine have demonstrated antibacterial activity against a wide variety of oral cavity bacteria including acid producing bacteria. This indicates its relevance to tooth protection specifically for the control of bacterial flora in the oral cavity in general. The products can be used in formulations to protect teeth and to treat the oral cavity: toothpastes, gels, mouthwashes, artificial saliva, for healthy patients and consumers. They have an attractive toxicological profile compared to fluoride and can be used in food systems; They also assist in the action of fluoride. Use in combination with fluoride provides excellent and improved protection at minimum fluoride dosage. The invention encompasses competent protein, peptide and saccharide structures based on in vitro and in vivo experiments, as well as production procedures and application conditions. |
| priorityDate | 2004-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.