| abstract |
(3-OXO-3,4-DIHYDRO-QUINOXALIN-2-YLAMINO) -BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS, AS GLYCOGEN PHOSPHORILASE INHIBITORS FOR TREATMENT OF DIABETES AND OBESITY. The present invention relates to pharmaceutically active quinoxalinones of formula (I), compositions containing them, and methods for making and using them. Formula (I), where R 1 is H, alkyl of <sym> or halo; R¬ 3¬ is H or alkyl of <sym>; X is N or CH; Y is a covalent bond, -NHCO- or -CONH-; Z is phenyl or a 5- or 6-membered heterocyclyl of 1 to 2 heteroatoms, independently selected from N, O and S; and n is 0, 1 or 2; or a pharmaceutically acceptable salt, ester, amide, hydrate or solvate thereof; as well as its use as glycogen phosphorylase inhibitors, for the treatment of diabetes or obesity. |